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S
EROLOGICAL IMMUNE RESPONSES TO LEISHMANIA ANTIGENS IN VISCERAL LEISHMANIASIS

Stephan Theinert¹ , Michael Forgber¹ ²and Peter Walden*

ABSTRACT: The rapid progress of the genome sequencing projects for infectious agents including Leishmania increasingly guides molecular immunology research on immunodominant antigens for vaccines and new immunological diagnostics. We have used molecular genetic and proteomic approaches to map the overall antigenicity of Leishmania parasites in visceral leishmaniasis and to elucidate the immunological properties of specific antigens including immunodominance, variability and accessibility for targeted immune responses.


¹ Department of Dermatology, Charité – Universitätsmedizin
Berlin, Humboldt University, Charitéplatz 1, 10117 Berlin,
Germany, Tel.: +49-30-450 518 031; Fax: +49-30-450 518 932

² Current address: Lehrstuhl für Molekulare Tierzucht und
Biotechnologie, Genzentrum der LMU München, Feodor-Lynen
Str. 25, 81377 München, Germany.

* Corresponding author : e-mail : peter.walden@charite.de


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